2020, Vol. 3, Issue 1, Part C

Aim & objective: Hence the present study "A Randomised double-blind comparative study of efficacy of preanesthetic single dose Magnesium sulphate versus clonidine for suppression of sympathetic response to pneumoperitoneum in patients undergoing elective laparoscopic cholecystectomy",

Methodology: The Present study conducted in Yashoda Hospital, Malakpet during the period of 1st May 2016 to 1st June 2018, to compare the beneficial effects of Clonidine and magnesium sulphate. A total of 60 patients randomly allocated in two groups, to Magnesium sulphate (Group M) & Clonidine (Group C) of 30 each undergoing elective laparoscopic cholecystectomy, under GA were studied. Sex, age and weight were comparable in the two groups. There were no significant differences between the two groups with regard to demographic data such as sex, age and weight.

Results: Heart rates were on the lower side in Group M after induction, at 5 mins and 10 mins, 20 min after pneumoperitoneum and in the postoperative period as compared to Group C. Systolic blood pressure (SBP) is significantly lower in Group M patients after induction, 5 mins, 10 mins, 20 min after pneumoperitoneum and in the postoperative recovery period as compared to Group C. In Group M, Diastolic blood pressure (DBP) is significantly lower at 5 mins, 10 mins,20 min after pneumoperitoneum and in the postoperative period as compared to Group C. Mean arterial pressure(MAP) is significantly lower in Group M patients at 5 mins, 10 mins, 20min after pneumoperitoneum and in the postoperative recovery period as compared to Group C. In our study, two patients in group C developed bradycardia which was not statistically significant.

Conclusion: Both the drugs, Clonidine as well as magnesium sulphate, provided adequate analgesia and maintained cardiovascular stability throughout the intraoperative period during laparoscopic cholecystectomy and were found to be safe.