2020, Vol. 3, Issue 1, Part D

Aims: Objective is to compare the efficacy of intravenous Dexmedetomidine in attenuating the cardiovascular response to laryngoscopy and endotracheal intubation.

Method: Study was done on 60 adults, ASA grade I or II normotensive patients, undergoing elective surgery under general anaesthesia and willing to participate. These patients were be randomly allocated in to either group C (Control), or D (Dexmedetomidine). Group ‘C’ Control group. Group ‘D’, patients were given intravenous Dexmedetomidine infusion 1 mcg/kg over 10 minutes, 3 minutes before start of laryngoscopy. All patients were premedicated, induced and intubated using Thiopentone and Succinyl Choline as per the protocol. Heart rate (HR), SBP, DBP and MAP were recorded at baseline (taken half an hour prior to anaesthesia), Before sedation, After induction but before intubation, Immediately after endotracheal intubation and Thereafter at 1, 2, 3, 4, 5 and 10 minutes.

Results: There was statistically significant rise in Heart rate after intubation in Group C compared to Group D, and difference was significant. After intubation, Heart rate continued to decrease and was significantly lower in Group D. There was statistically significant rise in MAP immediately after intubation in Group C compared to Group D.

Conclusion: We conclude that intravenous Dexmedetomidine 1 ug/kg is adequate to attenuate hemodynamic response to laryngoscopy and intubation.