2018, Vol. 1, Issue 2, Part A
to study gabapentin vs. pregabalin for acute post-operative pain control in lower limb procedures under spinal anaesthesia: A prospective comparison
Author(s): Ravindra Kumar and J Benjamin
Abstract: Introduction and Background: Postoperative pain management improves recovery, reduces opioid use, and reduces complications after spinal anaesthesia lower limb procedures. Gabapentin and pregabalin will be compared for acute postoperative pain management, opioid-sparing effects, and side events.
Materials and Methods: 90 patients going under spinal anaesthesia for elective lower limb procedures were part of a prospective, randomised, comparative study. From August 2017 through July 2018, researchers at India's Dr Pinnamaneni Sidhartha Institute of Medical Sciences (Department of Anaesthesiology) held their study in Vijaywada, Andhra Pradesh. Different groups of patients were assigned to each group: Those in the gabapentin group (n=45) were given 600 mg of gabapentin orally two hours before surgery. Two hours before surgery, patients in the pregabalin group (P, n=45) took 150 mg of oral pregabalin. We tracked the overall opioid use, the time to first analgesic request, and the need for rescue analgesia.
Results: The vagal index scores of the gabapentin group were substantially higher than those of the pregabalin group at 2, 4, 8, 12, and 24 hours. At 8 hours, the pregabalin group had an average VAS score of 2.3±0.8, while the gabapentin group had an average score of 3.8±1.1. In comparison to the gabapentin group, which consumed 125.6±18.4 mg of tramadol in 24 hours, the pregabalin group consumed 86.2±15.7 mg. In contrast to the gabapentin group, which needed their first analgesic dose at 6.4±1.2 hours, the pregabalin group's patients needed it at 9.2±1.5 hours. The groups did not differ significantly with respect to oxygen saturation, heart rate, or blood pressure.
Conclusion: For procedures involving the lower limbs performed under spinal anaesthesia, gabapentin and pregabalin both considerably lessen the need for opioids and greatly enhance postoperative pain management. Pregabalin outperformed gabapentin in terms of analgesia, opioid sparing, and time until rescue analgesia was needed. Pregabalin caused mild drowsiness to a slightly greater extent, but it was well-tolerated. When it comes to managing pain after surgery, pregabalin might be the way to go for these individuals.
DOI: 10.33545/26643766.2018.v1.i2a.539
Pages: 80-83 | Views: 41 | Downloads: 23
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How to cite this article:
Ravindra Kumar, J Benjamin. to study gabapentin vs. pregabalin for acute post-operative pain control in lower limb procedures under spinal anaesthesia: A prospective comparison. Int J Med Anesthesiology 2018;1(2):80-83. DOI: 10.33545/26643766.2018.v1.i2a.539