2019, Vol. 2, Issue 2, Part A

Methodology: This Randomized parallel group double-blind controlled study was conducted on 60 patients of elective lower limb surgery. Group B received 0.5% bupivacaine +normal saline1ml of 0.9% and Group BM received 0.5% bupivacaine+ magnesium sulphate (1ml) containing 50mg Bupivacaine.

Results: Both the drugs provided post-operative analgesia. Time for onset of sensory block in the two groups and there was significant difference between two groups in respect of onset of sensory block. The onset of block was significantly less in group BM compared to group B. The mean onset of sensory block (mean ± SD) was Group B-15.57±2.27 minutes and Group BM-12.93±1.14 minute. The time for onset of motor block, duration of sensory block, duration of motor block and duration of analgesia in the two groups and there was no significant difference. Visual analogue scale (VAS) score, Verbal rating scale (VRS) score and no of rescue analgesia by the patients in the two groups and there was no significant difference.

Conclusion: Single dose epidural administration of 0.5% bupivacaine hydrochloride with 50mg magnesium sulphate produces predictable rapid onset sensory block with less side effect than plain 0.5% bupivacaine hydrochloride.