2020, Vol. 3, Issue 1, Part C

Introduction: Majority of the orthopedic surgeries are associated with significant blood loss due to the large amount of cut bone, soft tissue dissection, and prolonged operation time.

Aims and Objectives: To study efficacy of tranexamic acid in reducing perioperative blood loss in orthopedic surgeries.

Methodology: This was a cross-sectional study carried out in the patients undergoing the various orthopedic surgeries where more blood lost is anticipated during the one year period i.e. February 2018 to February 2019.

Group A: Given tranexamic acid (TXA) intravenously.

Group B: Given no any special drugs except routine management of patient. The statistical analysis was done by chi-square test and unpaired t-test SPSS 19- version software.

Result: In our study we have found The average age in both the groups was comparable i.e. 43.12±3.45 and 42.98±4.18 (p>0.05, t=0.98, df=48) and the male to female composition was also comparable i.e. 2.12:1 and 3.16:1 (X2=0.09, p>0.05,df=1). Pre-operative HB (mean ± SD)-12.98± 2.76 and 13.27± 1.76 (p>0.05,t=0.76,df=48); Pre-operative HC (mean ± SD)- 35.78±3.45 and 36.12±.76 (p>0.05,t=0.26,df=48) was comparable but the Post-operative HB(mean ± SD) was 10.87± 2.73 and 9.12±1.73 (P<0.01,t=4.29,df=48); Post-operative HC (mean ± SD)- 34.87±3.48 and 33.19± 2.65 (P<0.001,t=5.32,df=48); Post-operative blood lost in ml (mean ± SD)- 749± 43.78 and 457±39.19 (P<0.0001,t=9.87,df=48) was significantly differed in Group A as compared to Group B.

Conclusion: It can be concluded form our study that the patients who received TXA were significantly less blood lost peri-operatively assessed by the various parameters like post-operative HB, HC, blood lost.