2020, Vol. 3, Issue 3, Part B
A comparative study to know the effects of dexmedetomidine on hemodynamics in patients undergoing laparoscopic surgeries under general anaesthesia
Author(s): Dr. PG Raghavendra and Dr. Chandana MH
Abstract: Introduction: Dexmedetomidine is a highly selective α2 agonist with sedative, sympatholytic and analgesic properties making it an ideal anesthetic adjuvant. The aim of this study was to evaluate the effect of dexmedetomidine infusion on hemodynamic response to critical incidences such as laryngoscopy, endotracheal intubation, creation of pneumoperitoneum and extubation in patients undergoing elective laparoscopic surgeries.
Methods: Sixty patients of American Society of Anesthesiologists (ASA) physical grades I and II undergoing elective laparoscopic surgeries were randomly allocated into two groups of 30 patients each. Group NS patients received normal saline, group D received loading dexmedetomidine infusion at 1 mcg/kg for 15 min before induction, followed by maintenance infusion at a rate of 0.3mcg/kg/hr, continued till the end of surgery. Heart rate and mean arterial pressure (MAP) were noted preoperative, after bolus drug administration, 1 min after induction, 1 min after intubation, and after pneumoperitoneum at 15 min interval till the end of pneumoperitoneum and postoperative period. SPSS 17.0 version software was used for statistical analysis.
Results: In group NS, significant hemodynamic stress response was seen following laryngoscopy, tracheal intubation, creation of pneumoperitoneum and extubation. In group D, the hemodynamic response at all times was attenuated significantly.
Conclusion: Dexmedetomidine effectively attenuates hemodynamic stress response during laparoscopic surgery and thus is an efficient pre-anaesthetic medication and intraoperative adjunct.
Pages: 56-59 | Views: 1083 | Downloads: 525
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How to cite this article:
Dr. PG Raghavendra, Dr. Chandana MH. A comparative study to know the effects of dexmedetomidine on hemodynamics in patients undergoing laparoscopic surgeries under general anaesthesia. Int J Med Anesthesiology 2020;3(3):56-59. DOI: 10.33545/26643766.2020.v3.i3b.147