International Journal of Medical Anesthesiology
2020, Vol. 3, Issue 3, Part B
Comparative study between magnesium sulphate and dexmedetomidine for attenuation of vasopressor stress response during laryngoscopy and endotracheal intubation
Author(s): Dr. Poonam Ghodki and Dr. Vivek Manohar Sawle
Abstract: Direct laryngoscopy & endotracheal intubation mostly produces vasopressor stress response characterized by tachycardia & increased blood pressure, which is transient starting from 30 seconds after intubation and lasting upto 10 minutes. It is tolerated well by healthy people, but harmful in patients with hypertension, ischaemic heart disease, cerebrovascular disease.
Aim:To compare effectiveness of intravenous MgSO4 30mg/kg & Dexmedetomidine(DEX) 1mcg/kg in attenuating vasopressor stress response during laryngoscopy and endotracheal intubation to study effect on heart rate, blood pressure & record complication if any.
Methodology:Sixty patient aged between 18-65years scheduled for elective surgical procedures belonging to ASA class I and II and Mallampatti grade I and II were included in study group and randomly allocated in two groups. GroupD received DEX 1mcg/kg diluted to 10ml normal saline, iv over 10 minutes, 10 minutes before intubation. GroupM received 30mg/kg of MgSO4 diluted to 10ml with normal saline, iv over 10minutes, 10 minutes before intubation. Both groups were observed for changes in haemodymic parameters i.e.heart rate, systolic, diastolic & mean arterial pressure at 0, 2, 5, 10 minutes post intubation.
Results:Statistical analysis was performed using SPSS VERSION 20(USA). We observed that the changes in laryngoscopy & intubation were comparable in both groups (p>0.005). However heart rate was more controlled in groupD as compared to groupM (p<0.005).
Conclusion: MgSO4 is as effective as Dexmedetomidine to attenuate vasopressor stress response to laryngoscopy and ETI.
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How to cite this article:
Dr. Poonam Ghodki, Dr. Vivek Manohar Sawle. Comparative study between magnesium sulphate and dexmedetomidine for attenuation of vasopressor stress response during laryngoscopy and endotracheal intubation. Int J Med Anesthesiology 2020;3(3):63-67. DOI: 10.33545/26643766.2020.v3.i3b.149