2024, Vol. 7, Issue 3, Part C
The effect of adding epinephrine on the duration of spinal anaesthesia for patients undergoing total knee replacement
Author(s): Mahmood Saleh Mahmood and Anas Amer Mohammad
Abstract:
Background: Spinal anesthesia is popular for lower abdominal and extremity operations. The sympathomimetic catecholamine epinephrine can constrict blood vessels with local anesthetics. Its pharmacologic activities include alpha and β-adrenergic receptors. The study compared the effects of adding epinephrine to spinal anesthesia on sensory and motor nerve block, haemodynamic condition, and complications in total knee replacement patients.
Method: A convenient sample of 80 patients who underwent total knee replacement under spinal anaesthesia were enrolled and divided into two groups: the intervention group received 40 patients who received a four-ml solution containing 3.5 ml (17.5 mg) of bupivacaine 0.5% and 0.5 ml of epinephrine (100 micrograms), and the control group received 40 patients who received a standard saline solution. Blood pressure, pulse rate, nerve block duration, and postoperative nausea and vomiting were recorded.
Results: Before and during the first, fifth, tenth, and fifteenth minutes following the surgery, the study groups had similar blood pressure and heart rates. Sensory and motor nerve block duration was substantially longer in the intervention group than the control group. In the intervention group, nausea and vomiting were not substantially lower than in the control group.
Conclusion: The addition of epinephrine to spinal anaesthesia significantly prolonged the duration of sensory and motor nerve block. There were no significant effects of epinephrine on the haemodynamic state and the incidence of nausea and vomiting.
DOI: 10.33545/26643766.2024.v7.i3c.500
Pages: 162-165 | Views: 180 | Downloads: 78
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How to cite this article:
Mahmood Saleh Mahmood, Anas Amer Mohammad. The effect of adding epinephrine on the duration of spinal anaesthesia for patients undergoing total knee replacement. Int J Med Anesthesiology 2024;7(3):162-165. DOI: 10.33545/26643766.2024.v7.i3c.500