2019, Vol. 2, Issue 1, Part A
A study on compare the intubating conditions and duration of action, of suxamethonium, vecuronium and different doses of rocuronium in paediatric patients: in tertiary care hospital, Hyderabad
Author(s): Dr. Murtuza Khan and Dr. Farha Fatima
Abstract: Background: Suxamethonium, a depolarizing muscle relaxant has remained the undisputed drug for aiding intubation and an ideal drug for securing the airway because of its capabilities to produce excellent intubating conditions within 60 seconds & short duration of action but is contraindicated in certain clinical conditions because of its side effects. Aim: The present study was undertaken to compare the intubating conditions as well as duration of actions of Suxamethonium 1.5mg/kg, Rocuronium and Vecuronium, a new benzylisoquinolone non-depolarizing muscle relaxant with relatively rapid onset and short duration of action, 0.1mg /kg at 60 seconds. Methods: After institutional approval and informed consent, 75 ASA I and II of elective surgeries. Paediatric patients posted for elective surgeries were grouped into 25 patients each. We compared the intubating conditions and duration of action of Suxamethonium 1.5mg /kg, Rocuronium 0.6mg/kg and Vecuronium at 60 seconds. Cardiovascular responses and any side effects related to histamine release were also studied. Statistical analysis: Statistical tools used in present study are student’s’ test and ‘chi squared’ test. Results: Laryngoscopy was found to be easy in all the patients of groups I & II at 60 sec. But in group III it was found to be easy in 15 (60%) patients and difficult in 10 (40%) patients. An excellent score seen in all cases of Group II within 60 sec. In Group I 60% had excellent and 40% had good intubation condition within 60 sec. All the patients in group III had only good intubating conditions that were achieved at 120 sec in 60% and at 10 sec in 40% of the patients. Conclusions: The present study concluded that rocuronium in a dose of 0.6 mg/kg provides superior intubating conditions compared to its predecessor, vecuronium. However, suxamethonium has maintained its supremacy as the preferred agent for its crash induction. Despite its hemodynamic stability, vecuronium, in doses used for intubation, is hardly suitable as an agent for crash induction as none of the patients could be intubated at 60 or even 90 secs intubation could only be performed at 120 -150 sec, that too with slight diaphragmatic movement in almost all the cases and slight limb movement in 80% patients. Intubating score was only good in all the patients paralysed with vecuronium. Thus, we concluded that intubating conditions were clinically acceptable in 100% cases with suxamethonium in onset of action, but the overall quality of intubating conditions is better with suxamethonium.
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How to cite this article:
Dr. Murtuza Khan, Dr. Farha Fatima. A study on compare the intubating conditions and duration of action, of suxamethonium, vecuronium and different doses of rocuronium in paediatric patients: in tertiary care hospital, Hyderabad. Int J Med Anesthesiology 2019;2(1):06-10. DOI: 10.33545/26643766.2019.v2.i1a.18