2019, Vol. 2, Issue 2, Part C
Attenuation of cardiovascular response during laryngoscopy and intubation: A comparative study of I.V Esmolol and labetalol
Author(s): Kanhu Charan Patro and Seema Kumari K
Abstract: Introduction: Laryngoscopy and endotracheal intubation causes reflex responses in the cardiovascular system which leads to changes in the blood pressure, heart rate and sometimes arrhythmia. These responses are of short duration and may be of little consequence in young healthy patients but can be detrimental to patients with hypertension, coronary artery disease, raised intracranial pressure, cerebral aneurysm and bronchial asthma.
Materials and Methods: A prospective study conducted at Department of Anaesthesiology in a Tertiary care teaching hospital from March 2019 to October 2019. 80 patients of age group 18- 60 years belonging to ASA Grade I and II of either sex posted for elective surgeries of various surgical units requiring endotracheal intubation under general anaesthesia were considered for study in a randomised single blinded manner. They were divided into 2 groups consisting of 40 patients each.
Group I(E): Received I.V Esmolol Hydrochloride 0.5mg/kg diluted to 10 ml with normal saline.
Group II(L): Received i.v Labetalol Hydrochloride 0.25mg/kg diluted to 10 ml with normal saline.
Result: In the esmolol group the initial mean heart rate of 85.52±7.72 increased to 107.35± 10.35 at intubation and 109.65± 10.03 at 1 minute and then decreased to 101.2±5.10, 96.52±6.14, 93.27±4.03, 87±6.20 at 3,5,10 and 15 minute interval respectively. In the labetalol group the initial heart rate was 85.37±11.62 which increased to 97.47±12.92 at intubation and 99.35±12.92 at 1 minute. It gradually decreased to 91.45±9.84, 85.97±7.78, 76.4±9.15, 80.2±7.93 at 3, 5, 10 and 15 minute interval respectively.
Conclusion: Labetalol was better than esmolol in attenuating the increase in heart rate and systolic blood pressure. Both Labetolol and Esmolol were ineffective in attenuating the increase in diastolic blood pressure. Labetalol was superior to Esmolol in suppressing the magnitude and duration of haemodynamic response to laryngoscopy and intubation as evident from the changes in rate pressure product.
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How to cite this article:
Kanhu Charan Patro, Seema Kumari K. Attenuation of cardiovascular response during laryngoscopy and intubation: A comparative study of I.V Esmolol and labetalol. Int J Med Anesthesiology 2019;2(2):195-200. DOI: 10.33545/26643766.2019.v2.i2c.308