2019, Vol. 2, Issue 2, Part C

Materials and Methods: A prospective study conducted at Department of Anaesthesiology in a Tertiary care teaching hospital from March 2019 to October 2019. 80 patients of age group 18- 60 years belonging to ASA Grade I and II of either sex posted for elective surgeries of various surgical units requiring endotracheal intubation under general anaesthesia were considered for study in a randomised single blinded manner. They were divided into 2 groups consisting of 40 patients each.

Group I(E): Received I.V Esmolol Hydrochloride 0.5mg/kg diluted to 10 ml with normal saline.

Group II(L): Received i.v Labetalol Hydrochloride 0.25mg/kg diluted to 10 ml with normal saline.

Result: In the esmolol group the initial mean heart rate of 85.52±7.72 increased to 107.35± 10.35 at intubation and 109.65± 10.03 at 1 minute and then decreased to 101.2±5.10, 96.52±6.14, 93.27±4.03, 87±6.20 at 3,5,10 and 15 minute interval respectively. In the labetalol group the initial heart rate was 85.37±11.62 which increased to 97.47±12.92 at intubation and 99.35±12.92 at 1 minute. It gradually decreased to 91.45±9.84, 85.97±7.78, 76.4±9.15, 80.2±7.93 at 3, 5, 10 and 15 minute interval respectively.

Conclusion: Labetalol was better than esmolol in attenuating the increase in heart rate and systolic blood pressure. Both Labetolol and Esmolol were ineffective in attenuating the increase in diastolic blood pressure. Labetalol was superior to Esmolol in suppressing the magnitude and duration of haemodynamic response to laryngoscopy and intubation as evident from the changes in rate pressure product.