2020, Vol. 3, Issue 2, Part B
Effects of perioperative infusion of lidocaine versus dexmedetomidine on postoperative pain and recovery in patients undergoing laparoscopic cholecystectomy: A randomized trial
Author(s): Dr. Ruchi Kumari, Dr. Anju Romina Bhalotra and Dr. Shweta Dhiman
Abstract: Background: It is important to have good postoperative pain control and early recovery after laparoscopic cholecystectomy (LC). Intravenous lidocaine has anti-hyperalgesic, anti-inflammatory and analgesic effects while dexmedetomidine provides anti-nociception, analgesic, sedative and sympatholytic effects. Both these drugs can be used as adjuvants to improve recovery after LC.
Aim: To evaluate the effects of perioperative infusion of lidocaine versus dexmedetomidine in patients undergoing LC with regards to: postoperative pain scores, analgesic consumption and recovery profile.
Methods: Eighty patients of either sex, aged 20-60 years, ASAI and II undergoing LC were randomly allocated to Group L and Group D. In Group L, patients received intravenous lidocaine 1.5 mg kg-1 followed by an infusion of 2 mg kg-1 hr-1 and in Group D, patients were given 1 µg kg-1 dexmedetomidine followed by an infusion of 0.4 µg kg-1 hr-1. Postoperative sedation score, pain scores and analgesic consumption and quality of recovery were assessed.
Results:Postoperative sedation score, requirement of additional postoperative analgesia, nausea, vomiting and requirement of anti-emetics and the mean VAS score over 24 hours were comparable in both the groups. The time taken to achieve PADSS score ≥ 9 was 33.17 ± 6.27 mins in Group D versus 39.75 ± 11.17 mins in Group L (p=0.02). The combined QoR score was 199 ± 0.92 in Group D versus 196.65±2.16 in Group L (p=0.0001).
Conclusion:Perioperative infusions of lidocaine and dexmedetomidine were effective and safe adjuvants to improve recovery after LC. However, the postoperative recovery profile was better with dexmedetomidine infusion and it may be considered the superior adjuvant in outpatient laparoscopic surgery.
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How to cite this article:
Dr. Ruchi Kumari, Dr. Anju Romina Bhalotra, Dr. Shweta Dhiman. Effects of perioperative infusion of lidocaine versus dexmedetomidine on postoperative pain and recovery in patients undergoing laparoscopic cholecystectomy: A randomized trial. Int J Med Anesthesiology 2020;3(2):70-75. DOI: 10.33545/26643766.2020.v3.i2b.124