International Journal of Medical Anesthesiology
2020, Vol. 3, Issue 4, Part A
Effect of magnesium sulphate nebulization on the incidence of post-operative sore throat
Author(s): Dr. R Brindha, Dr. P Naveena, Dr. S Chiraag, Dr. M Senthilkumar, Dr. Anshul Gaur and Dr. R Shankar
Abstract: Background: Research trials have been conducted on various pharmacological and non-pharmacological measures for ameliorating POST with a varied success rate. Magnesium has antagonistic property towards NMDA receptors and hence it acts as anti-nociception and anti-inflammatory agent and so when used as premedication before surgery the incidence of POST could be reduced.
Aim: To assess the efficacy of magnesium sulphate nebuliser in reducing the incidence of post-operative sore throat.
Methodology: A total of 100 patients with ASA grade 1 & 2 in the age group of 18-60 years of either sex posted for elective surgeries lasting for the duration of 2hrs or more and requiring tracheal intubation were taken as our study subjects. The Patients in group A (n=50) were nebulised with 3ml of normal saline for 15 minutes, 5 minutes before induction of anaesthesia and similarly patients in group B (n=50) were nebulised with 3ml of solution containing 50 mg/mL of magnesium sulphate. Presence of sore throat was assessed at rest and at swallowing on immediate extubation, and at 2, 4 hours and 24 hours post extubation. In the postoperative ward, patients were also monitored for any drug related side effects.
Results: The incidence of POST was measured at 0hr, 2 hr, 4 hrs and at the end of 24 hrs post-operatively both at rest and at swallowing. It was found that the incidence of sore throat at rest among the normal saline group during was 80%, 80%, 70% and 66% during the above said period and among the magnesium sulphate group it was 44%, 30%, 8% and 0%. Similarly the incidence of sore throat during swallowing was found to be 88%, 84%, 76% and 70% in the normal saline group and in the magnesium sulphate group it was 50%, 32%, 10% and 0% and a statistical significant difference was observed in the incidence of POST between the two groups. The incidence was found to be significantly lesser in the MgSo4 group when compared to the normal saline group.
Conclusion: The use of magnesium sulfate in the form of nebulization as a pre-medication agent significantly reduces the incidence of POST compared to normal saline.
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How to cite this article:
Dr. R Brindha, Dr. P Naveena, Dr. S Chiraag, Dr. M Senthilkumar, Dr. Anshul Gaur, Dr. R Shankar. Effect of magnesium sulphate nebulization on the incidence of post-operative sore throat. Int J Med Anesthesiology 2020;3(4):23-26. DOI: 10.33545/26643766.2020.v3.i4a.161