International Journal of Medical Anesthesiology
2020, Vol. 3, Issue 4, Part B
A comparative study of two different doses of dexmedetomidine for attenuating the haemodynamic response to tracheal intubation
Author(s): Dr. Manisha Singh, Dr. Pradnya S Joshi, Dr. Sanhita J Kulkarni and Dr. VM Sasturkar
Back ground: Reflex sympathetic discharge caused by laryngo-pharyngeal stimulus with laryngoscopy may lead to hypertension and tachycardia. It is one of the cause for morbidity during general anesthesia. We in our study compared the two doses of Dexmedetomidine1 µg/kg and 0.5 µg/kg for attenuating this response.
Material and Methods: In this study ninety patients were randomly divided into two groups. Group A Received: 0.5µg/kg Injection Dexmedetomidine as bolus dose over 10 minutes & Group B - Received: 1µg/kg Injection Dexmedetomidine as a bolus dose over 10 minutes. The heart rate and blood pressure (Systolic, diastolic and mean) of the patient were noted at following intervals preoperative i.e. Baseline, during administration of the study drug at 2 minutes, 4 minutes, 6 minutes, 8 minutes, and 10 minutes, immediately at induction, At intubation and Post intubation at 1min, 5 min and 10 min. Statistical significance in mean difference was calculated using student’s t test. P value of < 0.05 was regarded as statistically significant and p < 0.001 was taken as highly significant.
Results: Compared to the baseline all the hemodynamic parameters (HR, SBP, DBP and MAP) showed decrease during administration of the study drug which continued throughout the study period except at intubation and 1 min post intubation in both the groups. These values still remained below the baseline value. Highly significant difference in heart rate in both the groups was noted at 5 and 10min post intubation Group B showing more decrease than A(p=0.000, 0.001). Same statistical significance is noted in systolic blood pressure at induction and at 10 min. post intubation (p=0.000, 0.000). Mean blood pressure (p=0.03, 0.03) and diastolic blood pressure (p=0.000, 0.001) also showed more decrease in Group B than A at 5 and 10 min post intubation with high statistical significance.
Conclusion: Dexmedetomidine in the dose of 0.5 µg/kg and 1µg/kg is effective in attenuating the hemodynamic response to laryngoscopy and tracheal intubation
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How to cite this article:
Dr. Manisha Singh, Dr. Pradnya S Joshi, Dr. Sanhita J Kulkarni, Dr. VM Sasturkar. A comparative study of two different doses of dexmedetomidine for attenuating the haemodynamic response to tracheal intubation. Int J Med Anesthesiology 2020;3(4):70-73.