2021, Vol. 4, Issue 1, Part A
A study to compare short term postoperative cognitive outcomes in paediatric patients using intravenous propofol versus inhalational sevoflurane in maintenance of general anaesthesia
Author(s): Dr. Karthikadevi N, Dr. Shalini Jain, Dr. Pooja Vaskle and Dr. KK Arora
Abstract: Postoperative cognitive dysfunction (POCD) is a newly diagnosed subtle impairment of memory, concentration, and speed of information processing after surgery. POCD in adults and geriatric population has been well established, but less explored in the paediatric age group. The aim of this study is to compare the effects of intravenous propofol and inhalational sevoflurane on short term postoperative cognitive outcomes in children.
Experimental approach: 80 paediatric patients aged 5 - 15 years of ASA grade I and II posted for surgeries under general anaesthesia except neurosurgery were randomly allocated into two groups with 40 patients in each group. Group A received intravenous propofol and Group B received inhalational sevoflurane for maintenance of general anaesthesia. Cognitive assessment tests were done using Wechsler's Intelligence Scale for Children (WISC-V) both preoperatively and postoperatively at 6hr, 12hr and 24hr respectively.
Major Findings: Comparison of various cognitive indices in Group A and B is significantly lower at 6 hours in comparison to the preoperative value. Comparison of various cognitive indices between preoperative and at 24 hours postoperative levels, in Group A and B showed that these parameters return to the preoperative state at 24 hours after surgery.
Conclusion: There is no significant postoperative cognitive decline in patients comparing the cognitive functions preoperatively and 24 hour postoperative levels when using intravenous propofol versus inhalational sevoflurane. There was a transient but significant decline noted in the cognitive functions at 6 hour postoperatively compared to the preoperative period, noticed equally with both groups.
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How to cite this article:
Dr. Karthikadevi N, Dr. Shalini Jain, Dr. Pooja Vaskle, Dr. KK Arora. A study to compare short term postoperative cognitive outcomes in paediatric patients using intravenous propofol versus inhalational sevoflurane in maintenance of general anaesthesia. Int J Med Anesthesiology 2021;4(1):35-43. DOI: 10.33545/26643766.2021.v4.i1a.194