2022, Vol. 5, Issue 2, Part A
A comparative study of intrathecal dexmedetomedine and magnesium sulfate as adjuvants to bupivacaine in total hip replacement
Author(s): Kanhaiya Kumar and Ajeet Kumar
Abstract: Background & Objectives: Spinal anaesthesia is a popular technique for providing anaesthesia for total hip replacement (THR). Intrathecal adjuvant is given along with local anaesthesia to prolong duration of block. Intrathecal administration of dexmedetomidine and magnesium sulphate is known to enhance duration of block without causing significant side effect. The purpose of this study was to assess the impact of intrathecal dexmedetomidine and magnesium sulfate on the onset and duration of spinal anaesthesia using bupivacaine. Methods: After IEC approval, a prospective, randomized, double blinded study was conducted on 120 ASA I and II adult patients undergoing THR under spinal anaesthesia. Patients were randomly divided into three groups: Group D received 0.1 ml (10 μg) Dexmedetomidine, Group M received 0.1 ml (50 mg) Magnesium sulfate and Group C received 0.1 ml normal saline as control. All the patients in this study received 15 mg of hyperbaric bupivacaine. Time for sensory onset, Time for motor onset, Duration of Sensory Block, Duration of Motor Block, Duration of Analgesia and Incidence of Side Effects were recorded.Results: The haemodynamic parameters like systolic blood pressure, diastolic blood pressure and mean heart rate for the groups were comparable. The onset of sensory and motor block were significantly the fastest for Group D (p< 0.0001). The duration of sensory and motor block were significantly longer for Group D as compared to both the groups (p< 0.0001). The duration of analgesia was significantly prolonged for Group D as compared to both groups (p< 0.0001).Conclusion: Dexmedetomidine added to spinal Bupivacaine shortens the time of recovery and motor onset. It prolongs the duration of both sensory and motor blockade. It also provides significant post-operative analgesia.
Pages: 14-19 | Views: 327 | Downloads: 170
Download Full Article: Click Here
How to cite this article:
Kanhaiya Kumar, Ajeet Kumar. A comparative study of intrathecal dexmedetomedine and magnesium sulfate as adjuvants to bupivacaine in total hip replacement. Int J Med Anesthesiology 2022;5(2):14-19. DOI: 10.33545/26643766.2022.v5.i2a.344