2022, Vol. 5, Issue 3, Part A

Endotracheal intubation and laryngoscopy are noxious stimuli and provoke cardiovascular and autonomic responses because of sympathoadrenal stimulation. Attenuation of significant increases in heart rate and blood pressure decreases the risk of complications.

Various pharmacological and non-pharmacological methods have been tried to attenuate hemodynamic response to laryngoscopy and endotracheal intubation. None of the approaches have proved to be ideal.

In view of it present study was undertaken to evaluate and compare effects of intravenous magnesium sulphate 30mg/kg and lignocaine 2mg/kg in attenuation of pressor response to laryngoscopy and endotracheal intubation.

Prospective randomized controlled study was conducted in which 60 American society of Anesthesiologist 1 patients, aged 18-60yrs, undergoing elective surgery under general anesthesia were selected. Patients were randomized into 2 groups: Group 1 with thirty patients who received MgSO4 30mg/kg and Group 2 with thirty patients who received lignocaine 2 mg/kg intravenous bolus. Anesthesia was induced using premedication glycopyrolate, midazolam, ondansetron injection Fentanyl was administered as analgesic agent. Study drug Injection mgso4 was administered 90sec before induction with injection propofol as induction agent followed by injection succinylscoline to facilitate intubation. Laryngoscopy and intubation response in both groups were studied by recording Heart Rate (HR), blood pressure (BP), at baseline,after administering drug, at laryngoscopy, after intubation, 1min,3min,5minsafter intubation.

Study revealed that Group 1 patients had significant decreasing trend in HR and MAP recorded till 5mins after intubation. Mgso4 has vasodilator properties and significantly suppresses release of catecholamines and hence can attenuate stress response to laryngoscopy and endotracheal intubation better than lignocaine.